JAMIE BARRETT Accounting for around 60% to 70% of cases of dementia, Alzheimer’s disease causes apathy and progressive loss of memory and cognitive function in later life. An estimated 50 million people worldwide have the disease, and in ageing populations this number will continue to rise, so there has been significant investment in this research topic. This has uncovered two unusual suspects that may allow us to treat the condition: the common herpes virus and bacteria that infect the gums. Early dementia research involved examining brain tissue after death. This linked Alzheimer’s to buildups of two proteins, known as tau and amyloid, in the brain. Deposits of tau create threads that join together and tangle up between neurons while deposits of amyloid clump together among cells to form plaques. In 198 4, this gave rise to the amyloid hypothesis, which suggests that these protein deposits directly cause Alzheimer’s. Subsequently, in the 1990s, large investments were made to develop ...
An Academic Blog for Watford Grammar School for Boys